926 CSF Rhinorrhoea After Endonasal Intervention to The Skull Base (CRANIAL): Multicentre Pilot Study

نویسندگان

چکیده

Abstract Introduction CRANIAL (CSF Rhinorrhoea After Endonasal Intervention to the Skull Base) is a prospective, multicentre observational study seeking determine: scope of skull base repair methods used, and corresponding rates postoperative CSF rhinorrhoea in endonasal transsphenoidal (TSA) expanded approaches (EEA) for tumours. Method A cohort pilot was carried out at eleven neurosurgical units, via NANSIG BNTRC collaboratives. Results 192 cases were included – 167 TSA (87%), 25 EEA (13%). The most common (MC) pathologies included: pituitary adenomas (n = 150/192), craniopharyngiomas 7/192) meningiomas 4/192). MC techniques used tissue glues 135/192, Tisseel®), grafts 94/192, fat or Spongostan™) vascularised flap (52/192, nasoseptal). These repairs frequently supported by nasal packs 127/192) lumbar drains 23/197). Biochemically confirmed occurred 10/167 (6%) 4/25 (16%) EEA. 5 required operative management diversion direct repair). Qualitative feedback largely positive (e.g., user-friendly data collection), demonstrating acceptability. Conclusions Our experience highlights acceptability feasibility CRANIAL. There clear precedent dissemination this project, order establish benchmark contemporary neurosurgery practice.

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ژورنال

عنوان ژورنال: British Journal of Surgery

سال: 2021

ISSN: ['1365-2168', '0007-1323']

DOI: https://doi.org/10.1093/bjs/znab135.034